By Eric T. Wong
This concise textual content offers a whole assessment of alternating electrical fields treatment -- often referred to as tumor treating fields -- for glioblastoma and different sorts of reliable tumor malignancies. Readers are given a basic realizing of this novel anti-cancer remedy modality via studying from medical trial info in addition to the actual and cellphone biology results on tumor cells while alternating electrical fields are utilized either in vitro and in vivo.
Chapters illustrate the physics in the back of electrical box propagation in area and different media. this can be through a evaluation of our present knowing of the electrical box results on dividing cells - together with the disruption of cytokinesis, right chromosome segregation and activation at the mobilephone floor chaperons that result in immunogenic mobilephone loss of life. information from part III trials for the therapy of recurrent and newly clinically determined glioblastomas are integrated, in addition to many of the ancillary post hoc analyses that have been played via a variety of investigators. the rest of the bankruptcy covers different good tumor malignancies, together with non-small telephone lung melanoma, pancreatic melanoma and ovarian melanoma, as this remedy modality is being utilized to systemic malignancies.
Alternating electrical Fields treatment in Oncology bargains oncologists, neurologists, radiation oncologists, biomedical engineers, mobile biologists and mitosis researchers the basics wanted for scientific practice.
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Additional resources for Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields
34. Hu X, Arnold WM, Zimmermann U. Alterations in the electrical properties of T and B lymphocyte membranes induced by mitogenic stimulation. Activation monitored by electrorotation of single cells. Biochim Biophys Acta. 1990;1021(2):191–200. 35. Ye H, Cotic M, Kang EE, Fehlings MG, Carlen PL. Transmembrane potential induced on the internal organelle by a time-varying magnetic field: a model study. J Neuroeng Rehabil. 2010;7:12. 36. Ye H, Cotic M, Fehlings MG, Carlen PL. Influence of cellular properties on the electric field distribution around a single cell.
In the case of time-varying or alternating electric fields, the relative permittivity is a complex parameter (with real and imaginary parts); it is a function of the angular frequency and is referenced to the permittivity of vacuum or that of free space ε0 as seen in Eq. 1b. 7a shows the relative permittivity as a function of the alternating field’s angular frequency (ω) written in both the real and imaginary parts, where i = -1 and w = 2p f . A more realistic way of expressing Eq. 7a is one that forms a relationship between the relative permittivity and conductivity for linear isotropic materials, as Eq.
Gascoyne PR, Pethig R, Burt JP, Becker FF. Membrane changes accompanying the induced differentiation of Friend murine erythroleukemia cells studied by dielectrophoresis. Biochim Biophys Acta. 1993;1149(1):119–26. 34. Hu X, Arnold WM, Zimmermann U. Alterations in the electrical properties of T and B lymphocyte membranes induced by mitogenic stimulation. Activation monitored by electrorotation of single cells. Biochim Biophys Acta. 1990;1021(2):191–200. 35. Ye H, Cotic M, Kang EE, Fehlings MG, Carlen PL.
Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields by Eric T. Wong