By E. Lütjen-Drecoll
The phenomenon of getting older is characterised through quite a few degenerative adjustments, which differentially impact the hugely really expert constructions in the eye, comparable to the basically mobile lens, the brain-derived retina and the connective tissue of the uvea and sclera. for this reason, the attention can function a great version method to check age-related degenerative illnesses. an summary article bargains with the molecular biology of alpha-B-crystallin, and unique articles provide extra perception into the distribution and attainable sensible value of nonlenticular alpha-B-crystallin. Retinal transplantation stories which may finally result in treatment for tapetoretinal degeneration and age-related macular degeneration are mentioned. additional, elements that impact the advance of the retinal tissues are investigated. And one other review examines cells of the deep lens fibers. This exact factor is an in-depth resource of data to ophthalmologists in learn and perform.
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Extra info for Aging and Age Related Ocular Diseases (Ophthalmologica, 1)
001) of outward current , reflecting the greater potency of iberiotoxin for blocking this channel . In human trabecular meshwork, the values were 42 B 8% (n = 5) for charybdotoxin (10 –7 mol/l), while iberiotoxin (10 –7 mol/l) blocked 44 B 6% (n = 9) of the total outward current. Statistically, no significant differences emerged between the species, either in the absolute levels of out- 46 Ophthalmologica 2000;214:33–53 ward current or in the contribution of the maxi-K channel to this current.
Endothelin 1, a potent vasoactive agent that contracts trabecular meshwork strips , also reduced ocular outflow. Bradykinin is generated by the action of the kallikrein-kinin system and known for its vasoactive properties. Intracameral administration of bradykinin is known to increase intraocular pressure  and to contract smooth-muscle tissue; in accordance with this, a drop in outflow facility in the model of the perfused anterior segment was observed . As in the contractility experiments, the net effect of epinephrine depended on the concentration used .
6). Inhibition of PKA-PKG by H-8 (5 W 10 –6 mol/l) and of the serine threonine kinase PKC by chelerythrine or NPC-15437 (both at 10 –6 mol/l) was also able to relax trabecular meshwork; these effects were additive to the effects of the inhibition of tyrosine kinase . Recently, it has been shown that trabecular facility is indeed increased after application of the nonselective serine threonine protein kinase inhibitors H-7 and staurosporine [27, 90, 91]. Interestingly, there were marked differences in the response of trabecular meshwork and ciliary muscle .
Aging and Age Related Ocular Diseases (Ophthalmologica, 1) by E. Lütjen-Drecoll