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By D. M. Aviado, M. S. Micozzi (auth.), Professor Dr. Lászlo Szekeres (eds.)

ISBN-10: 3642675840

ISBN-13: 9783642675843

ISBN-10: 3642675867

ISBN-13: 9783642675867

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Two ex-activators (norepinephrine and dopamine) are naturally present in the lung and have been considered as candidates for airway neurohumoral transmitters. Three ex-activators (norepinephrine, dopamine, and phenylephrine) are also p-stimulators but are dissimilar to epinephrine in that they activate the cardiac (PI) but not the bronchial or vascular (P2)-receptors. When these three ex- and PI-activators are used as vasopressor agents, there are potential effects on the pulmonary circulation associated in part with their cardiac action, and also with the indirect consequences of their vasopressor action.

The development of tolerance with repeated use of certain compounds has been reported. , 1959). Chronic abuse of epinephrine-containing formulations may result in permanent dilation of the mucosal vascular beds of the nose, due to selective p-activation, resulting in dependence. D. Direct Activators of Beta-Receptors So far in this chapter, adrenergic drugs that influence IX-receptors have been discussed. Differences among IX-activator drugs lie in varying degrees of stimulation of p-receptors as well.

It was reasonable to hypothesize that the misuse or abuse of isoproterenol aerosols can be fatal because the propellant sensitizes the heart to actions of the administered isoproterenol as well as the vagal reflex induced by the respiratory irritant properties of the propellant (see AVIADO, 1975). Although some manufacturers continue to use this toxic fluorocarbon to propel isoproterenol aerosols, others are dispensing isoproterenol in mechanical units free of the propellant. ll. Protokylol Protokylol was synthesized by BIEL et aI.

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Adrenergic Activators and Inhibitors: Part II by D. M. Aviado, M. S. Micozzi (auth.), Professor Dr. Lászlo Szekeres (eds.)

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